Exploring NFkB pathway as a potent strategy to mitigate COVID-19 severe morbidity and mortality

Submitted: 7 October 2020
Accepted: 25 April 2022
Published: 12 October 2022
Abstract Views: 469
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  • Mubarak Muhammad Department of Physiology, College of Medicine, University of Ibadan, Nigeria. https://orcid.org/0000-0003-0001-5408
  • Tasneem M. Hassan Department of Physiotherapy, Aminu Kano Teaching Hospital, Kano, Nigeria.
  • Sani S. Baba Department of Human Physiology, College of Health Sciences, Bayero University Kano, Nigeria.
  • Mustapha I. Radda Department of Human Physiology, College of Health Sciences, Bayero University Kano, Nigeria.
  • Mubarak M. Mutawakkil Pharmacology and Therapeutics, College of Health Sciences, Bayero University Kano, Nigeria.
  • Majida A. Musa Pharmacology and Therapeutics, College of Health Sciences, Bayero University Kano, Nigeria.
  • Sazaly AbuBakar Tropical Infectious Diseases Research and Education Centre, Higher Institution Centre of Excellence, Universiti of Malaya, Kuala Lumpur, Malaysia.
  • Shih Keng Loong Tropical Infectious Diseases Research and Education Centre, Higher Institution Centre of Excellence, Universiti of Malaya, Kuala Lumpur, Malaysia.
  • Ibrahim Yusuf Department of Pathology, Aminu Kano Teaching Hospital, Kano, Nigeria.

The pandemic of coronavirus disease 2019 (COVID-19), for which there does not appear to be an approved cure, the primary treatment options consist of non-pharmacological preventive measures and supportive treatment that are aimed at halting the progression of the disease. Nuclear factor kappa B (NFkB) presents a promising therapeutic opportunity to mitigate COVID-19-induced cytokine storm and reduce the risk of severe morbidity and mortality resulting from the disease. However, the effective clinical application of NFkB modulators in COVID-19 is hampered by a number of factors that must be taken into consideration. This paper therefore explored the modulation of the NFB pathway as a potential strategy to mitigate the severe morbidity and mortality caused by COVID-19. The paper also discusses the factors that form the barrier, and it offers potential solutions to the various limitations that may impede the clinical use of NFkB modulators against COVID-19. This paper revealed and identified three key potential solutions for the future clinical use of NFkB modulators against COVID-19. These solutions are pulmonary tissue-specific NFkB blockade, agents that target common regulatory proteins of both canonical and non-canonical NFkB pathways, and monitoring clinical indicators of hyperinflammation and cytokine storm in COVID-19 prior to using NFkB modulators.

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